Mechanics of Mucociliary epithelium in health and disease

Research topics

• Forces, fate and form

  How cell and tissue mechanics coordinate both cell fate and tissue morphogenesis

• When forces decide fate

  Understanding how mechanical forces regulate the timing of cell fate acquisition

• Shape meets genes

  Integrating scRNAseq data with morphological parameters to generate a multimodal model of cell fate acquisition

• Organoid models of disease

  Establishing new models of human respiratory pathologies using 3D organoids

• 1 September 2026 The lab has moved to Germany
• 20 September 2026 Preprint: StressNET
• 5 August 2026 PAK4 in The Journal of Cell Biology

• StressNET: an adaptable deep-learning model for mechanical stress inference in tissues

  Nicolás Aldecoa Rodrigo, Augusto Borges, Jerónimo R. Miranda-Rodríguez, Guilherme Ventura, Jakub Sedzinski, Hernán López-Schier, Osvaldo Chara

  bioRxiv, 2026 Preprint

• PAK4: A vanguard of epithelial vertex remodeling

  Raghavan Thiagarajan, Jakub Sedzinski

  The Journal of Cell Biology, 2026 Publication

• Charge Matters, but So Does Species: Amphibian Early Development under Exposure to Clean Dialyzed Nanoplastics

  Mohamed Helal, Jakub Sedzinski, Xiaoyu Duan, Shan Wang, Changzhu Wu, Henrik Holbech, Elvis Genbo Xu

  ACS ES&T Water, 2026 Publication