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Sedzinski Lab
Sedzinski Lab

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2026

6 papers

  • StressNET: an adaptable deep-learning model for mechanical stress inference in tissues

    Nicolás Aldecoa Rodrigo, Augusto Borges, Jerónimo R. Miranda-Rodríguez, Guilherme Ventura, Jakub Sedzinski, Hernán López-Schier, Osvaldo Chara

    bioRxiv, 2026 Preprint

  • PAK4: A vanguard of epithelial vertex remodeling

    Raghavan Thiagarajan, Jakub Sedzinski

    The Journal of Cell Biology, 2026 Publication

  • Charge Matters, but So Does Species: Amphibian Early Development under Exposure to Clean Dialyzed Nanoplastics

    Mohamed Helal, Jakub Sedzinski, Xiaoyu Duan, Shan Wang, Changzhu Wu, Henrik Holbech, Elvis Genbo Xu

    ACS ES&T Water, 2026 Publication

  • Protocol for inferring mechanical stresses in tissues using ForSys, an open-source Python tool

    Augusto Borges, Jerónimo R. Miranda-Rodríguez, Alberto S. Ceccarelli, Guilherme Ventura, Jakub Sedzinski, Hernán López-Schier, Osvaldo Chara

    STAR Protocols, 2026 Publication

  • Actin cross-linking organizes basal body patterning through anomalous diffusion transitions

    Raghavan Thiagarajan, Younes Farhangi Barooji, Poul Martin Bendix, Mandar M. Inamdar, Jakub Sedzinski

    bioRxiv, 2026 Preprint

  • Single-cell morphodynamics predict cell fate decisions during mucociliary epithelial differentiation

    Mari Tolonen, Ziwei Xu, Ozgur Beker, Varun Kapoor, Bianca Dumitrascu, Jakub Sedzinski

    Molecular Systems Biology 22(7), 1040–1069, 2026 Publication

    On the cover of Molecular Systems Biology

    Cover of Molecular Systems Biology, July 2026: a crystal ball holding cell shapes above a frog skeleton and tarot cards naming the cell types

2025

5 papers

  • Effects of n-3 Long-Chain Polyunsaturated Fatty Acid and Vitamin D Supplementation on Transcriptional Profiles of Human Lung Organoids

    Mina Ali, Martin Steen Mortensen, Ole Bæk, Nicklas Brustad, Tingting Wang, Liang Chen, Min Gyu Kim, Casper-Emil Tingskov Pedersen, Trevor D. Lawley, Athanasios Pasias, Jakub Sedzinski, Jakob Stokholm, Klaus Bønnelykke, Bo Chawes

    Metabolites, 2025 Publication

  • ForSys: Non-invasive stress inference from time-lapse microscopy

    Augusto Borges, Jerónimo R. Miranda-Rodríguez, Alberto S. Ceccarelli, Guilherme Ventura, Jakub Sedzinski, Hernán López-Schier, Osvaldo Chara

    iScience, 2025 Publication

  • Cell-context response to germ layer differentiation signals is predetermined by the epigenome in regionalized epiblast populations

    Niels Alvaro Menezes, Kathryn Johanna Peterson, Xiaogang Guo, Veronica Castiglioni, Adrija Kalviša, Katarzyna Filimonow, Karen A. Schachter, Christina Maria Anna Pia Schuh, Athanasios Pasias, Luca Mariani, Joshua M. Brickman, Jakub Sedzinski, Elisabetta Ferretti

    Nature Communications, 2025 Publication

  • Pancreatic alpha and beta cell fate choice is directed by apical-basal polarity dynamics

    Ulf Tiemann, Chenglei Tian, Florian Hermann, Martin Proks, Emilie Skovgaard, Ivan Kulik, Yilin Di, Jakub Sedzinski, Henrik Semb

    Developmental Cell, 2025 Publication

  • nf-core/marsseq: systematic preprocessing pipeline for MARS-seq experiments

    Martin Proks, José Alejandro Romero Herrera, Jakub Sedzinski, Joshua M. Brickman

    Bioinformatics Advances, 2025 Publication

2023

1 paper

  • A single-cell, time-resolved profiling of Xenopus mucociliary epithelium reveals nonhierarchical model of development

    Julie Lee, Andreas Fønss Møller, Shinhyeok Chae, Alexandra Bussek, Tae Joo Park, Youni Kim, Hyun-Shik Lee, Tune H. Pers, Taejoon Kwon, Jakub Sedzinski, Kedar Nath Natarajan

    Science Advances, 2023 Publication

2022

2 papers

  • Multiciliated cells use filopodia to probe tissue mechanics during epithelial integration in vivo

    Guilherme Ventura, Aboutaleb Amiri, Raghavan Thiagarajan, Mari Tolonen, Amin Doostmohammadi, Jakub Sedzinski

    Nature Communications, 2022 Publication

  • Emerging concepts on the mechanical interplay between migrating cells and microenvironment in vivo

    Guilherme Ventura, Jakub Sedzinski

    Frontiers in Cell and Developmental Biology, 2022 Publication

2018

1 paper

  • Protein localization screening in vivo reveals novel regulators of multiciliated cell development and function

    Fan Tu, Jakub Sedzinski, Yun Ma, Edward M. Marcotte, John B. Wallingford

    Journal of Cell Science, 2018 Publication

2017

1 paper

  • RhoA regulates actin network dynamics during apical surface emergence in multiciliated epithelial cells

    Jakub Sedzinski, Édouard Hannezo, Fan Tu, Maté Biro, John B. Wallingford

    Journal of Cell Science, 2017 Publication

2016

1 paper

  • Emergence of an Apical Epithelial Cell Surface In Vivo

    Jakub Sedzinski, Édouard Hannezo, Fan Tu, Maté Biro, John B. Wallingford

    Developmental Cell, 2016 Publication

2015

2 papers

  • Zeta-Tubulin Is a Member of a Conserved Tubulin Module and Is a Component of the Centriolar Basal Foot in Multiciliated Cells

    Erin Turk, Airon A. Wills, Taejoon Kwon, Jakub Sedzinski, John B. Wallingford, Tim Stearns

    Current Biology, 2015 Publication

  • Planar Pol(o)arity

    Jakub Sedzinski, John B. Wallingford

    Developmental Cell, 2015 Publication

2011

1 paper

  • Polar actomyosin contractility destabilizes the position of the cytokinetic furrow

    Jakub Sedzinski, Maté Biro, Annelie Oswald, Jean-Yves Tinévez, Guillaume Salbreux, Ewa K. Paluch

    Nature, 2011 Publication